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Comparison of prophylactic antiemetic effect of three medicines in surgical procedures

Comparison of prophylactic antiemetic effect of Granisetron, Dexamethasone and Metoclopramide in surgical procedures under general anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015042715281N3
Enrollment
183
Registered
2015-11-23
Start date
2015-05-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of anaesthesia. Other complications of anaesthesia

Interventions

Intervention 1: 3 mg granisetron intravenous. Intervention 2: 8 mg dexamethasone intravenous. Intervention 3: 10 mg metoclopramide intravenous.
Prevention
3 mg granisetron intravenous
8 mg dexamethasone intravenous
10 mg metoclopramide intravenous

Sponsors

Vice chancellor for research, International Branch of Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: men who were candidate for orthopedic surgeries, in the range of 16 to 65 years -old, were evaluated. The patients who are in ASA I, II classes. Patients who use antiemetic drugs 48 hours before operation and who had post operative nausea and vomiting record in previous surgeries, patients with motion sickness, migraine, diabetes mellitus and smokers were not included. Exclusion criteria: patients who were discharged immediately after recovery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nausea and vomiting. Timepoint: During 2 hours in recovery and 6 hours in surgical ward. Method of measurement: Fill questionnaire and visual scale.

Secondary

MeasureTime frame
Age. Timepoint: Before operation. Method of measurement: Fill questionnaire.;Weight. Timepoint: Before operation. Method of measurement: Balance.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Ebrahim Sadeghi

Shiraz University of Medical Sciences

esadeghi@sums.ac.ir+98 71 4334 2061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026