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Comparison of efficacy and side effects of Chlorhexidine mouthrinses with (Hexodine) and without Alcohol (Epimax)

A Clinical Trial Study of the Chlorhexidine Mouthrinses with Alcohol (Hexodine) and without Alcohol (Epimax) Effect on Gingival Clinical Parameters in Choronic Gingivitis Patients

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201504244877N27
Enrollment
32
Registered
2015-08-21
Start date
2012-05-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis. Chronic gingivitis

Interventions

Intervention 1: Intervention group: Epimax mouthwash (Non-Alcoholic Chlorhexidine 0 .12 %) made by Emad pharmaceutical Co. Instruction: 15 milliliter of mouthwash for 60 seconds, 2 times a day (every
Treatment - Drugs
Intervention group: Epimax mouthwash (Non-Alcoholic Chlorhexidine 0 .12 %) made by Emad pharmaceutical Co. Instruction: 15 milliliter of mouthwash for 60 seconds, 2 times a day (every 12 hours) for 2
Control group: Hexodine mouthwash (Alcoholic Chlorhexidine 0.12%) made by Donyaye Behdasht Laboratories co. Instruction: 15 milliliter of mouthwash for 60 seconds, 2 times a day (every 12 hours) for 2

Sponsors

Vice chancellor of Research, Isfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with gingivitis disease; age over 18 years; lack of systemic disease; no pregnancy; no previous periodontal treatment and systemic antibiotics therapy in the last 6 months; not being smoker. Exclusion criteria: the patient’s unwillingness to continue the treatment; being under other treatment and taking medications which may affect the result during the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Gingival Index (Löe and Silness score). Timepoint: Two weak after intervention. Method of measurement: Observation of index score.;Plaque index (o'leary). Timepoint: Two weak after intervention. Method of measurement: Observation of index score.;Lobene stain index. Timepoint: Two weak after intervention. Method of measurement: Observation of index score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Jaber Yaghini

Periodontal department, School of Dentistry, Isfahan University of Medical Sciences

j_yaghini@dnt.mui.ac.ir.+98 317922825

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026