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Effects of probiotics on inflammation and bleeding of gums and tooth plaque

Clinical evaluation of effects of probiotic lozenges on gingival inflammation, dental plaque and gingival bleeding

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015042318054N3
Enrollment
32
Registered
2015-11-22
Start date
2013-11-10
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Inflammation, Dental Plaque and Gingival Bleeding. Chronic periodontitis

Interventions

Intervention 1: In control group, one lozenge with the commercial name of Mentazine 500, made in Iran, with peppermint extract of %0.25, anise extract of %0.25 and liquorice extract of %5 was used as
Treatment - Drugs
In control group, one lozenge with the commercial name of Mentazine 500, made in Iran, with peppermint extract of %0.25, anise extract of %0.25 and liquorice extract of %5 was used as a placebo after
In case group, a probiotic lozenge with the commercial name of Evoraplus, made in America, was used with 600 Million CFU Probiora3® as its main ingredient. Patients took one lozenge for 14 nights afte

Sponsors

Vice chancellor for research, Guilan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
23 Years to 33 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: mild to average chronic gingivitis with a mean gingival index of 1 to 2 millimeters without losing adherence and without periodontal pocket; lack of any systemic illness such as coronary and respiratory diseases, hemorrhagic problems, liver or kidney issues; no antibiotic consumption 3 months prior to the test; not being pregnant or breast-feeding; lack of physical or mental disablement with interfering effects on good oral hygiene; being a non-smoker; having not used mouthwash 3 months prior to the test; no drug consumption with interfering effects; lack of orthodontic appliances; non mouth breathers; absence of severe dental crowding

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Dental plaque. Timepoint: One week before prophylaxis and at the end of two weeks. Method of measurement: Based on percentage and by using O'leary index (1972).;Gingival bleeding. Timepoint: One week before prophylaxis and at the end of two weeks. Method of measurement: Based on bleeding on probing and by using Ainamo and Bay (1975).;Gingival inflammation. Timepoint: One week before prophylaxis and at the end of two weeks. Method of measurement: Based on scores 0,1,2,3 and by using silness-loe (1963).

Secondary

MeasureTime frame
Changes in taste. Timepoint: One week after prophylaxis and at the end of two weeks. Method of measurement: Clinical observation.;Changes in gustatory system. Timepoint: One week after prophylaxis and at the end of two weeks. Method of measurement: Clinical observation.;Irritation of the mucous. Timepoint: One week after prophylaxis and at the end of two weeks. Method of measurement: Clinical observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboubeh Asgharniay Hassan Kiadeh

Guilan University of Medical Sciences

royaaa68@yahoo.com+98 13 4454 6396

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026