schizophrenia. schizophrenia
Conditions
Interventions
Intervention 1: Tablet Risperidone (6 mg/day) combined with 50 mg/day Pregnenolone as intervention group for 8 weeks. Intervention 2: Tablet Risperidone (6 mg/day) combined with placebo as control gro
Treatment - Drugs
Placebo
Tablet Risperidone (6 mg/day) combined with 50 mg/day Pregnenolone as intervention group for 8 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:1-women with Diagnosis of Schizophrenia based on DSM- 5 criteria; 2- Minimum Score of 60 on Positive and Negative Scale; 3- Age between 18-45; 4-Chronic Schizophrenia- duration of the disorder more than 2 years; 5-Minimum score of 20 in negative sub score. Exclusion criteria: 1-Any serious medical or neurological problem; 2- IQ less than 70; 3- Substance dependence during the last 6 months(except for nicotine and caffeine); 4-receiving oral antipsychotic medications during the last week or receiving any depot antipsychotic medication during the last month; 5-receiving ECT during the last 14 days ; 6-Hepatic and renal diseases; 7- History of thromboembolism ; 8- History of abnormal uterine bleeding, uterine or breast canser; 9-CVA; 10-Hormone replacement therapy; 11- Endocrine abnormality.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2-4-8 after beginig of treatment. Method of measurement: Positive and Negative Syndrome Scale (PANSS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Shahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed