Glaucoma. Glaucoma, Glaucoma suspect
Conditions
Interventions
Intervention 1: Intervention group: Latanoprost ophthalmic drop 0.005% dripping one drop in each eye every night for 3 months. Intervention 2: Control group: Timolol ophthalmic drop 0.5% dripping one
Treatment - Drugs
Intervention group: Latanoprost ophthalmic drop 0.005% dripping one drop in each eye every night for 3 months.
Control group: Timolol ophthalmic drop 0.5% dripping one drop in each eye twice a day for 3 months.
Sponsors
Vice chancellor for research and technology of Islamic Azad University of Shahrood
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Presence of open angle glaucoma symptoms; ocular hypertension includes patients with increased IOP; glaucomatous cupping (cup to disc ratio between 0.4 - 0.7; disc-cup asymmetry>0.2; notching of the rim; enlargement of the cup; bleeding of the rim of the disc; degeneration of the nerve fiber layer) Exclusion criteria: Secondary causes of increasing IOP; cup to disc ratio>0.7; IOP>30 mmHg in each stage of the disease; existing of any other ocular disorder except glaucoma; corrected vision less than 20/50; bradycardia; asthma; COPD; consumption of any drug affecting IOP for example beta blockers, corticosteroids, carbonic anhydrase inhibitors, nitrates and alpha 2 agonists; discontent of patient.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tonometry. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Applanation Haag-Streit tonometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Refraction. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Refractor.;Gonioscopy. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Slit lamp.;Appointment of cup to disc ratio. Timepoint: Before intervention, at the end of the third month, at the end of the sixth month. Method of measurement: Slit lamp.;Eye irritation. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Questionnaire and examination by slit lamp.;Blurred vision. Timepoint: Before intervention, if the first wash out period is needed every 2 weeks during 4 weeks, at the end of the first week, the first and third month, every 2 weeks during 4 weeks in the second wash out period and at the end of the first week, the first and third month after the second wash out period. Method of measurement: Questionnaire and examination by slit lamp. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegin Ebrahimi
Imam Hossein Hospital of Shahrood
Outcome results
None listed