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The effect of induced hypotensive anesthesia on blood loss in percutaneous nephrolithotomy

Investigating the Effect of Induced Hypotensive Anesthesia versus Normotensive Anesthesia on Perioperative Bleeding in Patients Undergoing Percutaneous Nephrolithotomy: A Randomized Controlled Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150420021869N7
Enrollment
62
Registered
2024-01-23
Start date
2023-08-23
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Calculus of kidney. Calculus of kidney

Interventions

Intervention 1: Intervention group: In this group, general anesthesia is administered as a standard IV injection of 4-5 mg/kg of sodium thiopental, 3 µg/kg of fentanyl and 0.15 mg/kg of cisatracurium.

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient candidate for percutaneous Nephrolithotomy (PCNL) Age of above 18 years

Exclusion criteria

Exclusion criteria: Coagulopathy Anatomical disorders that interfere with the proper positioning of the patient Any disease that makes inducing the controlled hypotension impossible during surgery Single kidney Ectopic kidney Active infection of the urinary system Pregnancy Hematological diseases Cardiovascular diseases Glomerular Filtration Rate of less than 60 cc/min

Design outcomes

Primary

MeasureTime frame
Perioperative blood loss. Timepoint: Post operative. Method of measurement: After surgery, we add 1000 units of heparin to the collection bucket to prevent coagulation of the washing solution. Then 5cc of washing liquid is added to the vial of EDTA (ethylenediamine triacetic acid) to estimate hemoglobin. Hemocue method is used to estimate intraoperative bleeding. In this method, the amount of hemoglobin in the lavage fluid is multiplied by the total volume of the lavage fluid used, and the result is divided by the volume of serum hemoglobin before the operation, and thus the total amount of blood lost will be determined.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshad Gholipour

Esfahan University of Medical Sciences

farshad.gholipoor@gmail.com+98 31 3669 7898

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026