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The effect of probiotic and antioxidant use on the semen parameters

A comparative study of probiotic and antioxidant use on the improvement of semen parameters in men with primary idiopathic infertility: a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150420021869N5
Enrollment
102
Registered
2021-10-14
Start date
2021-09-23
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Male infertility

Interventions

Intervention 1: Intervention group: Intervention group: In this group, patients receive one Familact capsule containing 500 mg of synbiotics made by Zist takhmir Pharmaceutical Company for 3 months. I

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Men with primary idiopathic infertility Age 18 to 45 years

Exclusion criteria

Exclusion criteria: Pyospermia History of testicular surgery History of chemotherapy or radiotherapy smoking History and current use of drugs that affect spermatogenesis such as tamoxifen, hcg, cytotoxic drugs such as immunosuppressants, anticonvulsants, androgens History of sexually transmitted diseases Epididymitis and orchitis Testicular trauma Prostatitis Reluctance to participate in the study Chromosomal abnormalities Pregnancy event during the study History of testicular torsion

Design outcomes

Primary

MeasureTime frame
Seminal fluid volume. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.;Sperm count. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.;Sperm concentration. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.;Sperm motility. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.;Sperm morphology. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.;DNA Fragmentation Index. Timepoint: before intervention and 3 months after intervention. Method of measurement: semen analysis.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshad Gholipour

Esfahan University of Medical Sciences

farshad.gholipoor@gmail.com+98 31 3669 7898

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026