Comparison of Effectiveness of Levetiracetam With Phenytoin in Postcraniotomy Seizure in the Patients with Supratentorial Brain Tumors :RCT-Single Blind

Comparison of Effectiveness of Levetiracetam With Phenytoin in Postcraniotomy Seizure in the Patients with Supratentorial Brain Tumors:RCT-Single Blind

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150419021837N1

Enrollment

Registered

2017-12-19

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison of Effectiveness of Levetiracetam With Phenytoin in Postcraniotomy Seizure in the Patients with Supratentorial Brain Tumors.

Interventions

Intervention 1: Intervention group: Prophylaxis of the drugs use begins from 5 days before the surgery to continues 90 days after the surgery.Levetiracetam Dosage:1gr Bid in the operation day then 500

Prevention

Intervention group: Prophylaxis of the drugs use begins from 5 days before the surgery to continues 90 days after the surgery.Levetiracetam Dosage:1gr Bid in the operation day then 500mg Bid IV OR Ora

Intervention group: Prophylaxis of the drugs use begins from 5 days before the surgery to continues 90 days after the surgery.Phenytoin dosage:loading dose10-15 mg /kg IV-maintenance 100mg tds IV OR O

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patients with age higher from 18years with Supratentorial Tumors need to Craniotomy&Liver & Renal function,Creatinine lower from1.5× upper limit of normal (ULN), Aspartate Aminotransferase lower from3× ULN, Alanine Aminotransferase lower from 3× ULN and Bilirubin lower from1.5× ULN)

Exclusion criteria

Exclusion criteria: History of Allergy to the Two Drugs,History of Seizere,Posterior Fossa Tumors,Pregnancy&History of Colostomy

Design outcomes

Primary

Measure	Time frame
Siezure. Timepoint: Days of 7,30&90 Post Craniotomy. Method of measurement: Observation by the nurse or physicion.	—

Secondary

Measure	Time frame
Complications of Skin ,Renal&Liver. Timepoint: Days of 7,30&90 Post Craniotomy. Method of measurement: Observation of Skin &Liver&Renal lab data.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Abolfazli

Tehran University of Medical Sciences

mehdiabolfali1366@gmail.com+98 21 8490 2272

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026