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The role of antibiotics in mandibular fractures

The role of postoperative antibiotics in prevention of infection at open reduction of mandibular compound fractures

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015041521787N1
Enrollment
75
Registered
2015-09-14
Start date
2015-09-11
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mandibular fracture. Lower jaw (bone)

Interventions

Intervention 1: Patients diagnosed with open fractures of the mandible were placed on two groups: Antibiotic group or non antibiotic group and they receive 2-5 day preoperatively 1gr Cefazolin IV qid
Treatment - Drugs
Placebo
Patients diagnosed with open fractures of the mandible were placed on two groups: Antibiotic group or non antibiotic group and they receive 2-5 day preoperatively 1gr Cefazolin IV qid. Antibiotics 1g
Patients diagnosed with open fractures of the mandible were placed on two groups: Antibiotic group or non antibiotic group and they receive 2-5 day preoperatively 1gr Cefazolin IV qid. Antibiotics 1

Sponsors

Vice chancellor for research, Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Open reduction and internal fixation; At least 1 fracture of mandible; Follow up of at least 5 weeks. Exclusion criteria: Infection during surgry; Gunshot wounds; Need for intensive care; Presence of an acute bacterial infection; Pathological fractures; Fracture of the skull base; History of malignancy/ radiation of the head and neck area; Immunosuppression; Reduced body weight; Kidney disease; Inter Maxillary Fixation; Insufficient follow up

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Infection. Timepoint: Follow up appointments were 1,3,5 weeks postoperatively. Method of measurement: Infection, Inflammation, Erythema, Fever, Drainage.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehrnoush Momeni Rouchi

Tehran university of medical science

m-nobari@student.tums.ac.ir ; minnobari@yahoo.com+98 21 8835 1150

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026