Chronic Anal fissure. Chronic Anal fissure
Conditions
Interventions
Intervention 1: Group 1:patients will be apply topical 2% Diltiazem cream twice a day for two weeks. Intervention 2: Group 2: patients will be apply 0.5% Minoxidil cream twice a day for two weeks.
Treatment - Drugs
Group 1:patients will be apply topical 2% Diltiazem cream twice a day for two weeks.
Group 2: patients will be apply 0.5% Minoxidil cream twice a day for two weeks.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:All the patiens that are of 15 to 65 years old who had suffered from anal fissure and werent recovered after 6 weeks. Exclusion criteria: Hypertensive patients; diabeties; vascular disease and heart failures; malignant patients; the patients with history of chemoterapy; the patients who taking ACEI or Diltiazem as a medication .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anal Bleeding. Timepoint: Befor intervention- 1,2 mo After intervention. Method of measurement: History.;Wound Healing. Timepoint: Befor intervention- 1,2 mo After intervention. Method of measurement: Mucosal wound coverage.;Anal pain. Timepoint: Befor intervention-1,2mo After intervention. Method of measurement: VAS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Iitching. Timepoint: Befor intervention-1,2mo After intervention. Method of measurement: 5-D pruritis scale.;Headache. Timepoint: Befor intervention-1,2 mo After intervention. Method of measurement: VAS.;Decrease in BP. Timepoint: Befor itervention-1,2 mo After intervention. Method of measurement: mm Hg.;Dizziness. Timepoint: Befor intervention-1,2 mo After intervention. Method of measurement: History.;Allergy. Timepoint: Befor intervention-1,2 mo After intervention. Method of measurement: History. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed