Diagnosis of Pulmonary artery emboli with lower doses of IV contrast media

Comparison of Vascular Enhancement and image quality of pulmonary CT angiography with 30 cc Omnipaque 350 mg/cc to 50 cc Omnipaque 350 mg/cc in a randomized clinical trial in patients suspicious of pulmonary artery emboli

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015041121699N1

Enrollment

100

Registered

2015-06-04

Start date

2014-12-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary artery embolism. Pulmonary embolism

Interventions

Intervention 1: Decrease in intravenous contrast media administration of current protocol of 64MDCT-pulmonary CT angiography, 100 kvp, 100 mA with care dose,perform it by using 30 cc of Omnipaque (Ioh

Diagnosis

Decrease in intravenous contrast media administration of current protocol of 64MDCT-pulmonary CT angiography, 100 kvp, 100 mA with care dose,perform it by using 30 cc of Omnipaque (Iohexol) 350 mg/cc

Current protocol of 64MDCT-pulmonary CT angiography, 100 kvp,100 mA with care dose, using 50 cc of Omnipaque (Iohexol) 350 mg/cc intravenously, flow rate 4 ml/s

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients aged more than eighteen years and less than one hundred, with an indication for pulmonary CT angiography, and their weight is lower than 85kg Exclusion criteria: Patients unable to give informed consent, patients with a known allergy to contrast agents, pregnant patients, those with irregular supra ventricular tachycardia or congestive heart failure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vascular enhancement of main, Rt main, lobar, segmental and subsegmental pulmonary arteries. Timepoint: Just after intervention. Method of measurement: CT number (hounsfield unit).;Homogeneity of intravascular contrast enhancement of pulmonary arteries from the central to the subsegmental level. Timepoint: Just after intervention. Method of measurement: Semi-quantitative scale (1. bad, no diagnosis possible; 2. poor, diagnostic confidence significantly reduced; 3. moderate, but sufficient for diagnosis; 4. good; and 5. excellent).	—

Measure

Time frame

Vascular enhancement of main, Rt main, lobar, segmental and subsegmental pulmonary arteries. Timepoint: Just after intervention. Method of measurement: CT number (hounsfield unit).;Homogeneity of intravascular contrast enhancement of pulmonary arteries from the central to the subsegmental level. Timepoint: Just after intervention. Method of measurement: Semi-quantitative scale (1. bad, no diagnosis possible; 2. poor, diagnostic confidence significantly reduced; 3. moderate, but sufficient for diagnosis; 4. good; and 5. excellent).

—

Secondary

Measure	Time frame
Diagnostic confidence of pulmonary artery embolism detection. Timepoint: After intervention, when all images are collected. Method of measurement: Semi quantitative scale (1. possible PE; 2. probable PE; and 3. definite PE).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Evazdavani

Ahvaz Jundishapur University of Medical Sciences

info@ajums.ac.ir davani.m@ajums.ac.ir+98 61 3336 7543

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026