Effect of autologe PRP with hyaluronic acid on knee osteoarthritis

Comparison the efficacy and durability of treatment effect of autologe PRP with low weight hyaluronic acid on knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015041121697N1

Enrollment

Registered

2015-07-14

Start date

2013-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Primary gonarthrosis, bilateral

Interventions

Intervention 1: Intervention group1: Plasma rich platelet (PRP) done for only one knee, the worth on., Three injection by two weeks interval will be done. PRP is prepared by Blood transfusion organi

Treatment - Drugs

Intervention group1: Plasma rich platelet (PRP) done for only one knee, the worth on., Three injection by two weeks interval will be done. PRP is prepared by Blood transfusion organization kits. 10

Intervention group2: we use hyaloronic acid (trade mark: Hialgan, made in Germany) in this group. Three injection will be done by 1 week interval.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Chronic pain or swelling for at leas 4 months before radiological findings; degenerative changes in radiology Exclusion criteria: Systemic disorders like diabetes, rheumatoid arthritis; varus or valgus in spine more than 5 degree; hematologic disorders; chronic heart diseases; infections; immune compromise; hemoglobin less than 11; platelet less than 150000; incomplete questionnaire; incomplete treatment course; no interest to participate; multi-arthritis; intra-articular injection of hyaloronic acid in last 6 months; intra-articular injection of steroid in last 3 months

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Knee pain. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: VAS questionnaire.;Knee stiffnes. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.;Knee function. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.	—

Measure

Time frame

Knee pain. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: VAS questionnaire.;Knee stiffnes. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.;Knee function. Timepoint: 0, 2 and 6 monts after injection. Method of measurement: WOMAC questionnaire.

—

Secondary

Measure	Time frame
Septic arthritis. Timepoint: 2 weeks after injection. Method of measurement: Inspection.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Hajihashemi

Shahid Beheshti University of Medical Sciences

hashemi.z@gmail.com00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026