Atrial Fibrillation. Atrial fibrillation and flutter
Conditions
Interventions
Intervention 1: Double blind clinical trial. Intervention 2: In the intervention group, 50 mg of N-acetylcysteine will be administered intravenously during the procedure, 24 and 48 hours after surgery
Treatment - Drugs
Double blind clinical trial
In the intervention group, 50 mg of N-acetylcysteine will be administered intravenously during the procedure, 24 and 48 hours after surgery, within 30 minutes.
In the control group, patients will receive intravenous infusion of normal saline as placebo, intra-operatively and also 24 and 48 hours after surgery.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patient's willingness to participate in the study and getting informed consent from them; Non-emergency CABG surgery; Using cardiopulmonary bypass pump; No history of cardiac tachyarrhythmias before surgery (including AF); Having sinus rhythm; Hemodynamic stability (50 MAP> and heart rate between 50-110); and age between 35 and 75 years. Exclusion criteria: Heart failure patients with ejection fraction (EF) less than 30%; History of COPD, Hyperthyroidism; Occurrence of postoperative MI; Need to pacemaker post-operatively; Re-operation for any reason; Previous history of heart surgery; Use of anti-arrhythmic drugs (with the exception of beta-blockers); Using Inotropic drugs more than the usual dose (epinephrine infusion more than 0.1 mcg / kg / min and dopamine and dobutamine infuson more than 10 mcg / kg / min)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Atrial Fibrillation. Timepoint: 72 hours after surgery and continued after discharge from the ICU. Method of measurement: By the senior nurse in open heart surgical intensive care unit prosperity and approved by the monitoring device by cardiologists. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum hsCRP. Timepoint: Preoperative and postoperatively in the first and third day. Method of measurement: With Elisa method and using Vidas. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Aria Soleimani
Mazandaran University of Medical Sciences
Outcome results
None listed