CABG with CPB. Other complications following infusion, transfusion and therapeutic injection
Conditions
Interventions
Intervention 1: Intervention1: Selenium group 600 µg selenium injected, before induction of anesthesia. Intervention 2: Intervention 2: control groupPlacebo) equivalent distilled water injected, befor
Treatment - Drugs
Placebo
Intervention1: Selenium group 600 µg selenium injected, before induction of anesthesia
Intervention 2: control groupPlacebo) equivalent distilled water injected, before induction of anesthesia
Sponsors
Vice chancellor for research of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 30-65 years old; ASA class 2-3 with 3 vessels occlusion and EF>40-45 % and normal preoperative level of selenium(for men:29-107µg/l and for women:27-150 µg/l ). Exclusion criteria: The pump more than 120 minutes; need to inotropic drugs; extubation over than 8-10 hours.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor alpha. Timepoint: Before induction, immediately after CPB, 24 and 48 hours after surgery. Method of measurement: Picogram per milliliter/Elisa metod.;IL-6. Timepoint: Before induction, immediately after CPB, 24 and 48 hours after surgery. Method of measurement: Picogram per milliliter/Elisa metod.;Glucose. Timepoint: Before induction, immediately after CPB, 24 and 48 hours after surgery. Method of measurement: mg/dl/autoanalasor RA-1000.;C-Reactive Protein. Timepoint: Before induction, immediately after CPB, 24 and 48 hours after surgery. Method of measurement: Reversed passive agglutination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbbas Sedighinejad
Guilan University of Medical Sciences
Outcome results
None listed