Condition 1: Traumatic spinal cord injury. Condition 2: Traumatic spinal cord injury. Condition 3: Traumatic spinal cord injury. Condition 4: Traumatic spinal cord injury. Condition 5: Traumatic spinal cord injury. Transport accidents Other external causes of accidental injury Other and unspecified injuries of thoracic spinal cord Other and unspecified injuries of cervical spinal cord Sequelae of injury of spinal cord
Conditions
Interventions
Intervention 1: Intravenous infusion of 10 microgram/kg/day G-CSF for 5 consecutive days. Intervention 2: Methylprednisolone is given as an initial intravenous bolus of 30 mg/kg administered over a pe
if treatment is begun between 3 to 8 hours after injury, the infusion is continued for 47 hours (for a total of 48 hours).
Treatment - Drugs
Intravenous infusion of 10 microgram/kg/day G-CSF for 5 consecutive days
Methylprednisolone is given as an initial intravenous bolus of 30 mg/kg administered over a period of 15 minutes. This is followed 45 minutes later by a 5.4 mg/kg per hour continuous infusion of methy
Sponsors
Vice Chancellor for Research and Technology of Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Acute traumatic spinal cord injury; Age between 18 to 65 years old Exclusion criteria: Presence of intracranial lesions such as tumor, infection, ischemia or trauma; Past history of massive blood loss with transfusion; Past history of leukopenia or thrombocytopenia; Past history of hepatic or renal dysfunction; Past history of sever heart failure; Presence of splenomegaly or past history of it; Any evidence of malignancy during past 5 years; Pregnancy or lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spinal cord injury grade. Timepoint: Before the intervention, 1 week after the intervention, 3 months after the intervention and 6 months after the intervention. Method of measurement: AIS grading system.;Sensory and motor function score. Timepoint: Before the intervention, 1 week after the intervention, 3 months after the intervention and 6 months after the intervention. Method of measurement: ASIA scoring system. | — |
Secondary
| Measure | Time frame |
|---|---|
| -. Timepoint: -. Method of measurement: -. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSiavash Dehghani
Guilan University of Medical Sciences
Outcome results
None listed