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Comparison of therapeutic results of letrozole, tamoxifen, estradiol and vitamin E regimen with letrozole, tamoxifen and estradiol regimen in stimulating ovulation in infertile women with polycystic ovary syndrome: a double-blind randomized clinical trial study

Comparison of therapeutic results of letrozole, tamoxifen, estradiol and vitamin E regimen with letrozole, tamoxifen and estradiol regimen in stimulating ovulation in infertile women with polycystic ovary syndrome: a double-blind randomized clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150407021653N20
Enrollment
90
Registered
2023-12-14
Start date
2024-01-30
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome.

Interventions

Intervention 1: Intervention group: People participating in the study are randomly divided into two groups A and B with equal sample size.For group A, from the third to the seventh day of the menstrua

Sponsors

Jahrom University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
40 Years to No maximum

Inclusion criteria

Inclusion criteria: Female gender Infertile who have not had a history of pregnancy after 12 months of unprotected intercourse Suffering from polycystic ovary syndrome At least 40 years old

Exclusion criteria

Exclusion criteria: Non-consent to participate in the study drug sensitivity to letrozole or tamoxifen or estradiol or vitamin E the existence of any other pathology that has led to infertility in the patient or his wife liver or kidney dysfunction diabetes mellitus type one or two Thyroid disordes congenital adrenal hyperplasia abnormal hysterosalpingography

Design outcomes

Primary

MeasureTime frame
Pregnancy. Timepoint: One day after the fall in menstruation. Method of measurement: ß-HCG titer test.

Secondary

MeasureTime frame
Follicle size, follicle number and follicle thickness. Timepoint: Days 3, 7 and 12 of the cycle. Method of measurement: sonography.;Multiple births. Timepoint: Week 6 of pregnancy. Method of measurement: sonography.;Drug side effects. Timepoint: The total time of the intervention. Method of measurement: Examination by the doctor and self-reported by the patient based on previous training.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactathar raskh

Jahrom University of Medical Sciences

a.rasekh@jums.ac.ir+98 71 5434 2006

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026