Sepsis/septic shock. Septic shock
Conditions
Interventions
Intervention 1: Patients in intervention group will receive co enzyme Q10 60 mg (two 30 mg capsules) (Nature made Co., USA) two times per day for 7 days. Both groups also will receive standard sepsis
Treatment - Drugs
Placebo
Patients in intervention group will receive co enzyme Q10 60 mg (two 30 mg capsules) (Nature made Co., USA) two times per day for 7 days. Both groups also will receive standard sepsis treatment based
Patients in control group will receive placebo (which will produce by pharmacy faculty) two times per day for 7 days. Both groups also will receive standard sepsis treatment based on international gui
Sponsors
Vice Chancellor for Research,Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Critically ill patients with sepsis (proved or suspected infection) plus at least 2 criteria from following conditions:Body temperature >38.3 c or 90 beat/min, Respiratory rate >20 breath/min or PaCO2 12000 cell/mm3, or 10% immature [band]cells, Sudden change of mental status, and Hypoglycemia (blood glucose2)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in biomarkers levels before and after intervention. Timepoint: Day 1, 3 and 7 of admission. Method of measurement: ELIZA Kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital lenght of stay. Timepoint: Until the end of hospital stay. Method of measurement: Day.;Duration of mechanical ventilation. Timepoint: Until extubation. Method of measurement: Day.;Mortality rate. Timepoint: Day 7 and 28. Method of measurement: Day. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sarah Mousavi
Isfahan University of Medical Science
Outcome results
None listed