Gastro-esophageal reflux disease. Gastro-esophageal reflux disease with esophagitis
Conditions
Interventions
Intervention 1: Psyllium: The population treated with psyllium will be given 5 mg of the bulking agent solved in hot tap water one hour before breakfast and dinner with a goal of bowel movements and a
Treatment - Drugs
Psyllium: The population treated with psyllium will be given 5 mg of the bulking agent solved in hot tap water one hour before breakfast and dinner with a goal of bowel movements and a complete sense
Omeprazole: The omeprazole group will receive twenty-milligram omeprazole capsules half an hour before breakfast and dinner.
Sponsors
Vice chancellor for research, Mashad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Symptomatic patients with minimum three years history of gastroesophageal reflux disease and functional constipation whose esophagitis in upper endoscopy will be confirmed. Exclusion criteria: History of or current gastrointestinal cancer; Hiatal hernia; Irritable bowel syndrome; Endocrine diseases (e.g., hypothyroidism); Drug-induced constipation; Psychological disorders; Cardiovascular diseases; Liver diseases; Renal diseases; Opiums abuse
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment reflux disease remission with constipation improvement. Timepoint: First day, 7th day, 14th day, 21th day, 28th day, 35th day,42th day, 49th day and 56th day after intervention. Method of measurement: History of heart burn and regurgitation(clinical symptoms of GERD) was taken. Then the visual scale was used for evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoumeh Salari
Mashhad University Of Medical Sciences
Outcome results
None listed