postoperation complications of respiratory system. Postprocedural respiratory disorder, unspecified
Conditions
Interventions
Intervention 1: The control group receives common ventilation with tidal volume= 9 ml/kg and respiratory rate adjustment with EtCO2= 30-35 cmH20 and PEEP=0. Intervention 2: Intervention group recieves
Treatment - Devices
The control group receives common ventilation with tidal volume= 9 ml/kg and respiratory rate adjustment with EtCO2= 30-35 cmH20 and PEEP=0.
Intervention group recieves lung protective ventilation with tidal volume=6 ml/kg and respiratory rate adjustment with EtCo2=30-35 cmH2o and PEEP=10 cmH2o. In the intervention group, the recruitment m
Sponsors
Vice chancellor for research, Iran university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are patients candidate for CABG operation under general anesthesia; Patient's satisfaction with participating in the study and doing the respiratory examinations; BMI< 30 kg/m² age more than 18 and under 70; No pregnancy; No emergent surgery; No previous respiratory system surgery; No history of chronic obstructive pulmonary disease; No sleep disorder; No History of immune suppressant therapy( chemotherapy or radiotherapy) in the last 2 months; No acute respiratory damage or acute respiratory distress syndrome; No repeated treatment with systemic corticosteroid; No liver or neuromuscular disorders; No alcohol or substance abuse; No anesthetic drugs allergy; No cigarette smoking (less than 10 pack/year). Exclusion criteria are Hemoglobin < 10; Albumin <3 g/dl; Continuous hemodynamic unstability; Resistant shock; Prediction of long term mechanical ventilation after the surgery; non-early extubation (more than 6 hours after end of the surgery).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications. Timepoint: after the surgery. Method of measurement: 3 or more of these six postoperative pulmonary complications: cough, discharge increase, dyspnea, chest pain, temperature more than 38C, heart rate >100 per minute. | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Clinical Pulmonary Infection Score. Timepoint: After the surgery. Method of measurement: According to mentioned parameteres : Glasco scale, Mean Arterial Pressure, need for vasopressor to support cardiovascular system,Serum Aspartate Transaminase Level, Liver bilirubin, Protrombin time and platlets, coagulation factors and serum creatine.;IL-6 levels. Timepoint: before, exactly after and also after 24 hours of the surgery. Method of measurement: laboratory. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed