MAJOR DEPRESSION. F32.2
Conditions
Interventions
Intervention 1: In intervention group , patients will receive ketofol (ketamine 0.5 mg/kg , propofol 0.5 mg/kg mixture )and the suuccynilcholine for relaxation. The patients will ventilate by
Treatment - Drugs
In intervention group , patients will receive ketofol (ketamine 0.5 mg/kg , propofol 0.5 mg/kg mixture )and the suuccynilcholine for relaxation. The patients will ventilate by bag and mask w
In control group the patients will receive propofol 1mg/kg with equal volume of ketamine that prepare by normal saline. The patients will ventilate by bag and mask with 100% of oxygen till the bitem
Sponsors
Vice Chancellor For Research OF Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria are the patients with major depression ; the age between 18-60; who meet the DSM-IV-R criteria and candidate for elective electroconvulsive therapy. The exclusion criteria are any cognition problem before ECT ;history of mental retardation; uncontrolled hypertension; history of recent ECT administration and patients with ASA class IV that will exclude from the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE mini mental Status exam. Timepoint: Before the electroconvulsive therapy and 5 and 24 hours after ECT procedure. Method of measurement: MMSE mini mental Status exam 24-30, NO COGNITIVE PROBLEM 23-18MILD COGNITIVE PROBLEM 0-17,SEVER COGNITIVE PROBLEM. | — |
Secondary
| Measure | Time frame |
|---|---|
| Seizure duration. Timepoint: seizure production. Method of measurement: based on time (sec). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Haghighi
Guilan University of Medical Sciences /RASHT /IRAN
Outcome results
None listed