Comparing effect of Dexmedetomidine and Labetalol on Intraoperative blood loss in Rhinoplasty

Comparing effect of Dexmedetomidine and Labetalol on Intraoperative blood loss and surgical field quality in Rhinoplasty: A double-Blinded Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150317021497N7

Enrollment

Registered

2022-07-16

Start date

2022-07-23

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Systolic blood pressure. Condition 2: Diastolic blood pressure. Condition 3: Heart rate per minute. Condition 4: Mean arterial pressure. Condition 5: Bleeding rate. Elevated blood-pressure reading, without diagnosis of hypertension Other abnormalities of heart beat Accidental puncture and laceration during a procedure, not elsewhere classified

Interventions

Intervention 1: Intervention group: Dexmedetomidine in the form of a vial of 200 micrograms in 2 cc has a sympatholytic effect and is used as an infusion at a dose of 1 microgram per kilogram of body

Eligibility

Sex/Gender

All

Age

17 Years to 40 Years

Inclusion criteria

Inclusion criteria: All subjects undergoing rhinoplasty surgery since the beginning of the study for 6 months 17-40 years

Exclusion criteria

Exclusion criteria: Drug sensitivity to Dexmedetomidine and labetalol People with systolic blood pressure of 90 mmHg and lower People with a heart rate of less than 60 beats per minute upon entering the operating room

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery,. Method of measurement: Mercury sphygmomanometer.;Diastolic blood pressure. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery. Method of measurement: Mercury sphygmomanometer.;Heart rate. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery. Method of measurement: Pulse oximeter.;Bleeding rate. Timepoint: During osteotomy, at the end of surgery. Method of measurement: The difference in the weight of the consumed substances will be used to check the amount of bleeding. (weight of sterile gases after use + weight of suctioned liquids during surgery) - (weight of dry gases before use + amount of normal saline serum for washing the surgical site).	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery,. Method of measurement: Mercury sphygmomanometer.;Diastolic blood pressure. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery. Method of measurement: Mercury sphygmomanometer.;Heart rate. Timepoint: Before the start of surgery, after intubation, 20 minutes after intubation, during osteotomy, at the end of surgery, in recovery. Method of measurement: Pulse oximeter.;Bleeding rate. Timepoint: During osteotomy, at the end of surgery. Method of measurement: The difference in the weight of the consumed substances will be used to check the amount of bleeding. (weight of sterile gases after use + weight of suctioned liquids during surgery) - (weight of dry gases before use + amount of normal saline serum for washing the surgical site).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Jadidi

Rafsanjan University of Medical Sciences

fa.jadidi.2020@gmail.com+98 34 3426 0080

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026