Comparison of Analgesic Effect of Ketorolac in Intravenous Injection and when Added to Lidocaine in Blocks in the Orthopedic Surgeries.

Comparison of Analgesic Effect of Ketorolac in Intravenous Injection and when Added to Lidocaine in Bier Block in Surgery for Traumatic Upper Extremity Injuries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015031419470N20

Enrollment

Registered

2016-04-26

Start date

2016-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopaedic Surgery. Fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate

Interventions

Intervention 1: Distilled water (DW) group: 3 mg / kg lidocaine 5.0 per cent in 5 ml of distilled water solution for Bier block intravenous (systemic). Intervention 2: Topical ketorolac group (RK): 3

Treatment - Drugs

Distilled water (DW) group: 3 mg / kg lidocaine 5.0 per cent in 5 ml of distilled water solution for Bier block intravenous (systemic).

Topical ketorolac group (RK): 3 mg / kg lidocaine 5.0 percent + 30 mg ketorolac as Bier block and 5 ml of distilled water for intravenous (systemic).

Ketorolac group venous (IVK): 3 mg / kg lidocaine 5.0 per cent as Bier block solution and 5 ml distilled water contains 30 mg of ketorolac for intravenous (systemic).

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients aged 20 to 60 years; patients undergoing orthopedic surgery for traumatic injuries of upper extremity; eligible for Bier block; ASA I-II; duration of the surgery will be less than 90 minutes; Patients patient's mental ability to collaborate and answered the questions. Exclusion criteria: Long-term use of analgesics (including opioid and non-narcotic); depression; Uncontrolled seizures; peripheral nerves diseases ;sensitivity to the study drugs; renal failure; lack of glucose-6-phosphate dehydrogenase; cardiovascular problems and infection in the injured limb; signs of nerve damage in the injured extremities; liver failure.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Analgesia prioperatively and post operatively. Timepoint: Every 10 min in the operating room and every 15 min in the recovery ,every one hour at the six first hour in the ward , every two hour after six to 12 hours and every 4 hour until 24 hour. Method of measurement: NRS.	—

Secondary

Measure	Time frame
Patient satisfaction. Timepoint: 24 hours after surgery. Method of measurement: Questionaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Ghadimi

Shiraz University of Medical Sciences

ghadimi.maryam@gmail.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026