Effect of botulinum toxin A injection versus no intervention on clinical sign in women with facial flushing

Effect of botulinum toxin A injection versus no intervention on clinical sign in women with facial flushing: a before after clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201503129014N59

Enrollment

Registered

2015-04-25

Start date

2015-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Flushing. Flushing

Interventions

Intervention 1: A single dose intradermal injection of 2 IU botulinum toxin A (Neuronox) in every 1 cm in each chin to a maximum of 30 IU. Intervention 2: Compared to before intervention.

Treatment - Drugs

A single dose intradermal injection of 2 IU botulinum toxin A (Neuronox) in every 1 cm in each chin to a maximum of 30 IU

Compared to before intervention

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) facial flushing; (b) female sex. Exclusion criteria: (a) carcinoid syndrome or thyroid medullary cell carcinoma; (b) pregnancy or breast feeding; (c) systemic diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical sign of flashing. Timepoint: before and one month after intervention. Method of measurement: using DLQI questionnaire.	—

Secondary

Measure	Time frame
Unintended facial paralysis or partial paralysis of lower eyelid. Timepoint: one month after intervention. Method of measurement: through history taking.;Strabismus. Timepoint: one month after intervention. Method of measurement: through history taking.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Leila Khezrian

Farshchian Hospital

khezrian.leila@yahoo.com+98 81 3827 4184

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026