Suicide attempt- Depression. Severe depressive episode without psychotic symptoms, Personal history of self-harm
Conditions
Interventions
Intervention 1: Intervention group: 0.5 mg/kg IV ketamine/30 min and the patient is monitored for 2, 24, 72 hrs and 7 days for adverse drug reactions. Intervention 2: Control group: 500 cc IV normal s
Treatment - Drugs
Intervention group: 0.5 mg/kg IV ketamine/30 min and the patient is monitored for 2, 24, 72 hrs and 7 days for adverse drug reactions.
Control group: 500 cc IV normal saline as placebo
Sponsors
Vice chancellor for research, Hormozgan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: depression diagnosis due to DSM IV criteria; benign major depression episode; suicidal thoughts; no use of antidepression drugs in last month; age above 18 Exclusion criteria: bipolar disorder type 1 & 2; cyclothymia; psychosis having other disorder of 1or 2 axis simultaneusly; drug addiction or withdrawal; medical disease which causes depression; pregnancy; breast feeding; cardiovascular disease history
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of suicidal thoughts. Timepoint: 2, 24, 72 hours and 7 day after drug injection. Method of measurement: Beck suicidal ideation questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantity of depression. Timepoint: 2, 24, 72 hours and 7days after drug injectinon. Method of measurement: Beck depression questionaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarah Moayedi
Hormozgan University Medical Sciences
Outcome results
None listed