Investigation of interavenous Ketamine anti depressant effects on major depressive disorder patients

Compression the efficacy of ketamine as bolus versus infusion with 0.5 mg /kg and 0.75 mg /kg in treatment of the major depressive disorder.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015030921072N2

Enrollment

100

Registered

2015-04-04

Start date

2015-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder. Severe depressive episode without psychotic symptoms

Interventions

Intervention 1: Group 1= Single dose 0.5 mg/kg IV bolus. Intervention 2: Group 2= Single dose o.75 mg/kg IV bolus. Intervention 3: Group 3= Single dose 0.5 mg/kg IV infusion. Intervention 4: Group 4=

Treatment - Drugs

Group 1= Single dose 0.5 mg/kg IV bolus

Group 2= Single dose o.75 mg/kg IV bolus

Group 3= Single dose 0.5 mg/kg IV infusion

Group 4= Single dose 0.75 mg/kg IV infusion

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with major depressive disorder according to DSM-V criteria with different severity and with out psychotic feature were selected.this patient also lacks a somatoform disorder and personality disorder co-morbidity, hypertension and heart disease and over the last month are not under medical treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Depression. Timepoint: Pre intervension, 2, 7, 30, 60 dayes post intervension. Method of measurement: Hamilton and Beck test.	—

Secondary

Measure	Time frame
Drug dose. Timepoint: Pre intervension, 2, 7, 30, 60 dayes post intervension. Method of measurement: Hamilton and Beck test.;Method Of Injection. Timepoint: Pre intervension, 2, 7, 30, 60 dayes post intervension. Method of measurement: Hamilton and Beck test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGooya Tayyebi

Shahid Yahyanejad Hospital

G.Tayyebi@yahoo.com+98 11 3229 1951

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026