Condition 1: cancer of colorectal. Condition 2: pripheral neuropathy. Malignant neoplasm of rectosigmoid junction Drug-induced polyneuropathy
Conditions
Interventions
Intervention 1: in intervention group :vitamin E 400 mg daily. Intervention 2: Control group were observed.
Prevention
in intervention group :vitamin E 400 mg daily
Control group were observed
Sponsors
Vice Chancellor for research of Isfahan of University Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : 18 to 75 years of age ; diagnosed with colorectal cancer ; scheduled to receive oxaliplatin-based regimens (FOLFOX 4) ; had more than 6 month life expectancy exclusion criteria : previous history of peripheral neuropathy ; symptomatic peripheral neuropathy at entry into the study ; received other chemotherapy regimens ; currently receiving anticoagulants ; platelet aggregation inhibitors ; opioids ; anticonvulsants ; tricyclic antidepressants ; previous history of hemorrhagic stroke
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral neuropathy. Timepoint: before study and then 3 months later. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZeinab Salehi
Isfahan University of Medical Sciences
Outcome results
None listed