Neoplasms. Malignant neoplasm of small intestine, Malignant neoplasm of colon, Malignant neoplasm of rectosigmoid junction, Malignant neoplasm of rectum
Conditions
Interventions
Intervention 1: group two take a combination of probiotic and honey (two probiotic capsules and 30 grams honey per day, one capsule and 15 grams honey in the morning after breakfast and another one ca
two probiotic capsules per day, one capsule in the morning after breakfast and another one in the evening.
Treatment - Drugs
group two take a combination of probiotic and honey (two probiotic capsules and 30 grams honey per day, one capsule and 15 grams honey in the morning after breakfast and another one capsule in the eve
group three are the control group receive two placebo capsules (containing 500 mg of corn starch) per day, one capsule in the morning after breakfast and another one in the evening
group one take probiotics )contained: Lactobacillus casei 1.5 × 109 CFU, Lactobacillus acidophilus 1.5 × 1010 CFU, Lactobacillus rhamnosus 3.5 × 109 CFU, Lactobacillus bulgaricus 2.5 × 108 CFU, Bifido
two probiotic capsules per day, one capsule in the morning after breakfast and another one in the evening
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria: Patients with pelvic cancers (colorectal, prostate, endometrial, bladder, ovary, cervical, bone sarcoma) who undergo pelvic radiotherapy. The exclusion criteria: The presence of any acute or chronic gastrointestinal condition associated with diarrhea before recruitment and getting pelvic radiotherapy in the past.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diarrhea grade. Timepoint: Weekly from one week before radiotherapy until end of treatment. Method of measurement: Common Toxicity Criteria system.;Stool consistency score. Timepoint: Weekly from one week before radiotherapy until end of treatment. Method of measurement: Bristol scales.;Blood cell counts. Timepoint: Weekly from one week before radiotherapy until end of treatment. Method of measurement: cell counter machine.;Serum IgA level. Timepoint: Weekly from one week before radiotherapy until end of treatment. Method of measurement: Autoanalyzer machine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bloting. Timepoint: Weekly during treatment. Method of measurement: Question from the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHajar-Alsadat Mansouri-Tehrani
University of Isfahan
Outcome results
None listed