Comparison of the effect of oral zinc sulfate on the prevention of chemotherapy-induced oral mucositis

Evaluation of the effect of oral zinc sulfate with placebo on the prevention of chemotherapy-induced oral mucositis in patients treated with adriamycin and cyclophosphamide

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150304021338N2

Enrollment

Registered

2021-02-11

Start date

2021-02-18

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer. Malignant neoplasm of breast of unspecified site

Interventions

Intervention 1: Control group: when starting chemotherapy treatment, patients take two placebo capsules(Alhavi Company) daily with food for 12 weeks. Intervention 2: Intervention group: when starting

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having a biopsy-confirmed cancer. Candidate for chemotherapy containing adriamycin and cyclophosphamide Having a normal serum zinc level Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Infection of the oral mucosa before the study

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Visual Analog Scale (VAS).;Incidence of oral mucositis. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Observation.;Quality of Life. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Cancer Patients Quality of Life Questionnaire.	—

Measure

Time frame

Pain. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Visual Analog Scale (VAS).;Incidence of oral mucositis. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Observation.;Quality of Life. Timepoint: Before starting chemotherapy and once every three weeks for up to 12 weeks. Method of measurement: Cancer Patients Quality of Life Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Roayaei

Esfahan University of Medical Sciences

Roayaei@med.mui.ac.ir+98 31 3776 7396

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 11, 2026