Condition 1: Pain intensity after gastric or pancreatic neoplasm resection. Condition 2: Resectable malignant neoplasm of head of pancreas. Condition 3: Resectable malignant neoplasm of stomach. Pain localized to upper abdomen Malignant neoplasm of head of pancreas Malignant neoplasm of stomach
Conditions
Interventions
Intervention 1: no injection into control group during operation. Intervention 2: Injection of 20cc of prepared ethanol solution to each of celiac ganglions at both sides of supra-pancreatic portion o
Placebo
Treatment - Drugs
no injection into control group during operation
Injection of 20cc of prepared ethanol solution to each of celiac ganglions at both sides of supra-pancreatic portion of aorta.
Sponsors
Vice chancellor for research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Resectable pancreatic cancer or gastric cancer; Obtaining informed consent for probable alcohol injection during surgery. Exclusion criteria: Unresectable pancreatic cancer; Unresectable gastric cancer; Patients those who underwent neo-adjuvant chemotherapy; Patients who dissatisfaction with the procedures; Patients who expires before 4 month after operation; Prolonged post-operation hospitalization (more than 15 days) due to surgical complications; Age less than 15 or more than 80 year; History of prolonged consumption of opioids, NSAIDS, analgesic and anti-depressant drugs; Cardiac or pulmonary diseases; Sensitivity to opioid drugs; Psychological disorders; Abnormal arterial blood gas analysis; Happening of surgical complications or any other signs that results in disability to complete pain scale questionnaire (such as loss of consciousness).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of abdominal pain. Timepoint: Before surgery, one, two and four days after surgery, discharge time, one, two and four months after surgery. Method of measurement: Visual Analogue Scale (VAS) questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization time. Timepoint: Discharge time. Method of measurement: Number of days that patient stays at hospital after surgery.;Gastroparesia. Timepoint: Along first 72 hours after surgery. Method of measurement: Nausea, vomiting and volume of nasogastric tube secretions.;Arrhythmia or bradycardia. Timepoint: Along 72 hours after surgery. Method of measurement: Electrocardiography and cardiac monitoring.;Blood pressure. Timepoint: Every 30 minutes along 72 hours after operation. Method of measurement: Systolic and diastolic blood pressure will be measured by stethoscope and aneroid sphygmomanometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Saraee
Firouzgar General Hospital
Outcome results
None listed