Effect of letrozole versus no intervention on implantation in infertile women with poor ovarian response candidate for in vitro fertilization

Effect of letrozole versus no intervention on implantation in infertile women with poor ovarian response candidate for in vitro fertilization: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201502259014N56

Enrollment

Registered

2015-03-09

Start date

2013-01-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intravenus decapeptide 0.1 ml daily for 2 days and then intravenous gonadotropin 300 to 450 IU daily for 5 days. Intervention 2: Intravenous decapeptide 0.1 ml daily for 2 days and the

Treatment - Drugs

Intravenus decapeptide 0.1 ml daily for 2 days and then intravenous gonadotropin 300 to 450 IU daily for 5 days

Intravenous decapeptide 0.1 ml daily for 2 days and then intravenous gonadotropin 300 to 450 IU daily for 5 days plus letrozole 5 mg daily for 5 days

Eligibility

Sex/Gender

Female

Age

35 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) age older than 35 years; (b) FSH level =10 IU/ml; (c) ovarian volume <3 ml; (d) number of ovule less than3 to 5; (e) estradiol level less than 500 to 100 pg/ml. Exclusion criteria: (a) contraindication for pregnancy; (b) having systemic diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pregnancy. Timepoint: 4 months after intervention. Method of measurement: using pregnancy test.	—

Secondary

Measure	Time frame
Measuring the number of ovules. Timepoint: 4 months after intervention. Method of measurement: using ultrasonography.;Measuring the number of embryos. Timepoint: 4 months after intervention. Method of measurement: using ultrasonography.;Measuring the endometrial thickness. Timepoint: 4 months after intervention. Method of measurement: using ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fatemeh Aliasgari

Fatemieh Hospital

f.aliasgari@umsha.ac.ir+98 81 3827 7459

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026