Moderate to advanced periodontitis in smokers. Factors influencing health status and contact with health services
Conditions
Interventions
Intervention 1: In the control proup after measuring the indexes and doing SRP we give placebo to the patiants ,for the first day 4 tablets then thy use 1 tablet per day for 6 days. Intervention 2: Pa
Placebo
Treatment - Drugs
In the control proup after measuring the indexes and doing SRP we give placebo to the patiants ,for the first day 4 tablets then thy use 1 tablet per day for 6 days
Participants in the intervention group received 2g tinidazole as loading dose in the first day and then Participants in the test groupreceived 500 mg tinidazole to be taken once daily for 6 days..
Sponsors
Shiraz University of Medical Sciences, International Branch
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: sixty systemically healthy individuals with untreated moderate-to-advanced periodontitis were recruited into the study based on the following criteria: 1)patients do not use antibiotics in last 2 months. 2)do not have periodontal disease in last 6 months. 3)do not have systematic disease including: diabetes, hypertension, heart disease and other infectious diseases 4)participants should be current smokers(are defined as persons who had smoked at least 100 cigarettes in their lifetime and reported that they were smoking at the time of interview. Exclusion criteria: 1) pregnancy or lactation; 2) systemic diseases (such as diabetes mellitus); 3) systemic antibiotics taken within the previous 2 months; 4) use of non-steroidal anti-inflammatory drugs; 5) confirmed or suspected intolerance to 5-nitroimidazole derivatives; and 6) subgingival SRP or surgical periodontal therapy in the previous 6 month.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GI Leo and Silness was measured. Timepoint: Baseline visit and six weeks later. Method of measurement: According to the color of gingiva and use of probe.;PI Oleary was measured. Timepoint: Baseline visit and six weeks later. Method of measurement: By disclosing tablet.;Before scaling and root planning , Strict oral hygiene instructions (OHI) were instituted on all participants at the same time by the operator. Timepoint: Baseline visit and six weeks later. Method of measurement: Measured by use of Williams probe. Recession and PD recorded in all present teeth in six sites (mesio-buccal, midbuccal, disto-buccal, mesio-palatal/lingual, mid-palatal/ lingual, and disto-palatal/lingual) in each patient of both groups by the same person.disclosing tablets was used for evaluating PI in four surfaces of teeth(mesial, distal, buccal,lingual/palatal).BI lenox was measured in four sites (mesial, distal, mid buccal and mid palatal/lingual) in all present teeth.GI index evaluated in six teeth(mandibular first molar,first premolar ,central incisors and maxillary first molar ,first premolar and cetral incisors).;BI Lenox was measured. Timepoint: Baseline visit and six weeks later. Method of measurement: By using probe.;Attachment level was measured. Timepoint: Baseline visit and six weeks later. Method of measurement: PD+ recession.;Recession was measured. Timepoint: Baseline visit and six weeks later. Method of measurement: By using probe.;PD measured. Timepoint: Baseline visit and six weeks later. Method of measurement: By probing. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArmaghan Tarjan
Shiraz University of Medical Sciences, International Branch
Outcome results
None listed