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Effect of prophylactic infusion of phenylephrine on mothers’ hemodynamic at Caesarean section with spinal anesthesia

Effect of prophylactic infusion of phenylephrine on mothers’ hemodynamic at Caesarean section with spinal anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015022414333N29
Enrollment
80
Registered
2015-03-11
Start date
2014-06-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anesthesia. Other complications of spinal and epidural anaesthesia during pregnancy

Interventions

Intervention 1: In the experiment group, 12.5 milligram anesthetic bupivacaine hyperbaric 0.5 was injected intrathecally using 25-spinal needle in L4-L-5 environment and patients immediately were set
in the case of hypotension, common treatment with ephedrine is used to control blood pressure. Immediately after intrathecal injection of the anesthetic, mothers were measured and recorded for their v
Treatment - Drugs
In the experiment group, 12.5 milligram anesthetic bupivacaine hyperbaric 0.5 was injected intrathecally using 25-spinal needle in L4-L-5 environment and patients immediately were set in supine positi
In the control group, Phenylephrine was not injected

Sponsors

Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion: single pregnancy, BMI larger than 20and less than 35, over 36 weeks of pregnancy, patients at their 18 to 40, patients’ satisfaction. Exclusion: coagulopathy or infection in spinal or any other contraindications to spine anesthesia, sensitivity to phynylephrine and bupivacaine, mothers’ hypertension, cardiovascular diseases, cerebrovascular disease, congenital abnormalities of the fetus, diabetic mothers

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Mothers systolic blood pressure. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: By monitoring device.;Mothers diastolic blood pressure. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: By monitoring device.;Mothers heart bit. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: By monitoring device.;Oxygen saturation in mothers. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: By monitoring device.;Nausea and vomiting. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: Based on the observations by the doctor and asking the patients.;Infant apgar. Timepoint: 1, 5 and 10 minutes after delivery. Method of measurement: Based on the observations by the doctor.;Sensory block level. Timepoint: 1, 3, 5 and 30 minutes after spinal anesthesia. Method of measurement: Based on the observations by the doctor.;Mean arterial pressure. Timepoint: Beginning to the study, every minute till the delivery and every three minutes to the end of the study. Method of measurement: By monitoring device.

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026