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Effect of high dose versus low dose Atorvastatin therapy on inflammatory & coagulatory factors in type 2 diabetic patients

Effect of high dose versus low dose Atorvastatin therapy on inflammatory & coagulatory factors in type 2 diabetic patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201502226710N5
Enrollment
200
Registered
2015-05-22
Start date
2014-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetic. Diabetes mellitus

Interventions

Intervention 1: In the first group tablet Atorvastatin (40-80 milligram) daily will be prescribed. Intervention 2: In the second group tablet Atorvastatin (10-20 milligram) daily will be prescribed.
Treatment - Drugs
In the first group tablet Atorvastatin (40-80 milligram) daily will be prescribed
In the second group tablet Atorvastatin (10-20 milligram) daily will be prescribed

Sponsors

Vice chancellor for research, Tabriz University of Medical Sciences Daneshgah Square Tabriz
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with type2 diabetes mellitus LDL>70 ; age>18y ;TG 1 mth) Exclusion criteria: type 1 diabetes Mellitus; chronic liver disease(liver enzymes more than 3 time the upper limit of normal , B or C Hepatitis ); renal failure Cr>2;pregnancy;lactation ; Chronic inflammatory diseases such as rheumatic diseases (rheumatoid arthritis and systemic lupus erythematosus); Patients with a history of anti-inflammatory drugs; In case of muscle pain and increased risk of rhabdomyolysis in patients with CPK elevation; unwillingness to participate in the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Low density Lipoprotein. Timepoint: At baseline and after 3 months of treatment. Method of measurement: Test.;Cholestrol. Timepoint: At baseline and after 3 months of treatment. Method of measurement: test.

Secondary

MeasureTime frame
Inflammatory markers. Timepoint: At baseline and after 3 months of treatment. Method of measurement: test.;Coagulatory factor. Timepoint: At baseline and after 3 months of treatment. Method of measurement: test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mitra Niafar

Tabriz University of Medical Sciences

niafarm@TBZmed.ac.ir+98 41 3335 7850

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026