Effect of infusion of B-type Natriuretic Peptide in Acute Exacerbation of Asthma

Bronchodilator Effect of B-Type Natriuretic Peptide in Acute Asthma Attack Patients (Randomized Controlled Trial Phase I & II)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015022215446N2

Enrollment

Registered

2015-10-07

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Exacerbation of Asthma. Asthma

Interventions

Intervention 1: Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20

Treatment - Drugs

Control Group: Salbutamol 2.5mg each 20 minutes with nebulizer Atrovent 2.5mg each 20 minutes with nebulizer Prednisolone 50mg by mouth one time MgSO4 2g intravenous infusion in 20 minutes

Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20 minutes BNP 2mc

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Acute Asthma Attack with: Age above 18 years old; Clinically or Para-clinically Asthma History Exclusion Criteria: History of Cardiovascular Diseases; History of COPD; History of other pulmonary diseases; History of Smoking more than 10 years; Pregnant women; History of hypersensitivity to the BNP; Systolic Blood Pressure less than 100 mmHg

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Forced Expiratory Volume in First Second (FEV1). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.;Peak Expiratory Flow Rate (PEFR). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.	—

Measure

Time frame

Forced Expiratory Volume in First Second (FEV1). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.;Peak Expiratory Flow Rate (PEFR). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter.

—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Before Intervention. Method of measurement: Millimeter of Hg.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hassan Motamed

Ahvaz University of Medical Sciences

motamed-h@ajums.ac.ir+98 61 3374 3079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026