valuation the effect of melatonin in prevention of vancomycin induced nephrotoxicity

Evaluation the effect of melatonin in prevention of vancomycin induced nephrotoxicity in critically ill patients: A randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150221021159N4

Enrollment

Registered

2020-06-27

Start date

2018-07-23

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney failure. Acute kidney failure, unspecified

Interventions

Intervention 1: Intervention group: Melatonin tablets made in nature made company are administered orally at the dose of 3 mg twice daily for 7 days, on the same date of starting colistin. Interventio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients who received intravenous vancomycin. Creatinine clearance more than 45 milliliter per minute at study recruitment Oral tolerance to the drug

Exclusion criteria

Exclusion criteria: Receiving intravenous vancomycin or melatonin for at least 2 weeks before study recruitment Acute kidney injury before study recruitment

Design outcomes

Primary

Measure	Time frame
Acute kidney failure based on changes of serum neutrophil gelatinase-associated lipocalin (NGAL) levels. Timepoint: At the initial of study (before initiation of colistin) and 7 days after intervention. Method of measurement: ELISA Kit.;Acute kidney failure based on changes of serum creatinine levels. Timepoint: At the initial of study (before initiation of colistin) and 7 days after. Method of measurement: Creatinine assay kit.	—

Measure

Time frame

Acute kidney failure based on changes of serum neutrophil gelatinase-associated lipocalin (NGAL) levels. Timepoint: At the initial of study (before initiation of colistin) and 7 days after intervention. Method of measurement: ELISA Kit.;Acute kidney failure based on changes of serum creatinine levels. Timepoint: At the initial of study (before initiation of colistin) and 7 days after. Method of measurement: Creatinine assay kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShadi Farsaei

Esfahan University of Medical Sciences

Farsaei@pharm.mui.ac.ir+98 31 3792 7071

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026