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The effect of Nigella Sativa on treatment of Hashimoto thyroiditis

The effect of supplementation with Nigella Sativa on serum Nesfatin-1, vascular endothelial growth factor (VEGF) and insulin resistance in patients with Hashimoto in comparison of placebo treated group

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015021719082N4
Enrollment
40
Registered
2015-03-15
Start date
2014-12-27
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hashimoto Thyroiditis. Autoimmune Thyroiditis

Interventions

Intervention 1: Placebo: 1 gram per day starch as placebo for four weeks treatment period. Intervention 2: Supplement: one gram per day Nigella Sativa for four weeks treatment period.
Treatment - Drugs
Treatment - Other
Placebo: 1 gram per day starch as placebo for four weeks treatment period
Supplement: one gram per day Nigella Sativa for four weeks treatment period

Sponsors

Research Undersecretary of Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: (Inclusion criteria: aged between 20-50 years old; physician diagnosis of hashimoto thyroiditis; completeing written informed consent) (Exclusion criteria: pregnancy, lactation, taking supplements such as vitamin E, C, zinc, folate, cobalamin and phytoesterogens in past three months;any history of celiac, cardiovascular disease, arthritis, autoimmune and inflammatory disease; thyroid abnormalities and surgeries and being on diet)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nesfatin-1. Timepoint: before and 4 weeks after intervention. Method of measurement: ELIZA method.;Vascular Endotheilal Growth Factor (VEGF). Timepoint: Before and 4 weeks After Intervention. Method of measurement: ELIZA method.

Secondary

MeasureTime frame
Fasting Blood Sugar. Timepoint: Before and Four Weeks After Intervention. Method of measurement: Enzymatic Method.;Insulin Resistance. Timepoint: Before and Four Weeks After Intervention. Method of measurement: HOMA-IR.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mahdieh Abbasalizad Farhangi

Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences

abbasalizad_m@yahoo.com+98 41 3335 7580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 11, 2026