the effect of intravenous diphenhydramine and ondansetron on nausea and vomiting

A comparison of the effect of intravenous diphenhydramine and ondansetron on post middle ear surgery nausea and vomiting

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150217021121N5

Enrollment

100

Registered

2020-08-05

Start date

2020-07-22

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting. Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention 1: Intervention group:In this group, they will receive 4mg of intravenous ondansetron before induction of anesthesia. Intervention 2: Control group:In this group, 50 mg of diphenhydramine

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All people aged 18 to 60 are candidates for middle ear surgery Has ASA grade,class I&II

Exclusion criteria

Exclusion criteria: History of nausea and vomiting after surgery History of migraine headache History of digestive problems Pregnant and in menstruating period History of motion sickness Take anti-nausea medication 48 hours before surgery

Design outcomes

Primary

Measure	Time frame
Severity of postoperative nausea and vomiting. Timepoint: In the post-anesthesia care department every 24 hours for 24 hours after surgery. Method of measurement: Based on scoring (0 = no nausea and vomiting, 1 = nausea, 2 = vomiting and 3 = vomiting more than 2 times.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Movvassaghi

Tabriz University of Medical Sciences

rz_movassaghi@yahoo.com+98 41 3334 1994

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026