Antibacterial effect of sodium hypochlorite 6% plus chlorhexidine 0.2% and calcium hydroxide powder versus sodium hypochlorite 6% alone on the endodontic lesion in patients with apical periodontitis

Antibacterial effect of sodium hypochlorite 6% plus chlorhexidine 0.2% and calcium hydroxide powder versus sodium hypochlorite 6% alone on the endodontic lesion in patients with apical periodontitis: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201502169014N55

Enrollment

Registered

2015-02-23

Start date

2014-09-13

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apical periodontitis. Acute apical periodontitis of pulpal origin

Interventions

Intervention 1: Irrigation of root canal with 10 ml sodium hypochlorite 6% plus chlorhexidine 0.2% and calcium hydroxide powder. Intervention 2: Irrigation of root canal with 10 ml sodium hypochlorite

Treatment - Drugs

Placebo

Irrigation of root canal with 10 ml sodium hypochlorite 6% plus chlorhexidine 0.2% and calcium hydroxide powder.

Irrigation of root canal with 10 ml sodium hypochlorite 6%.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) having single-rooted tooth with pulp necrosis and apical periodontitis; (b) having a negative response to pulp test; (c) presence of radiographic lesion. Exclusion criteria: (a) receiving antibiotic during the last three months; (b) extensive decay or fracture of the crown or root; (c) tooth with previous root canal repair; (d) teeth with probing more than 4 mm in depth.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Evaluation of Enterococcus faecalis colonization. Timepoint: 2 weeks after treatment. Method of measurement: using bacterial counts.	—

Secondary

Measure	Time frame
Nothing. Timepoint: Nothing. Method of measurement: Nothing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Parastoo Ghahari

Dentistry School

ghahariparastoo@yahoo.com+98 81 3838 1039

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026