Coronary artery bypass grafting. Complications of cardiac and vascular prosthetic devices, implants and grafts
Conditions
Interventions
Intervention 1: Intervention group 1: In the paracetamol group, the patients receive the drug 15 mg/kg at maximum 1 gram intravenously every 6 hours after arrival at ICU for 24 hours. Intervention 2:
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult older than 18 years undergoing off-pupm CABG ASA class 2 or 3 Non-synthetic opium abuse
Exclusion criteria
Exclusion criteria: Allergy to either of drugs Consumption of either drugs in the past 48 hours Preoperative use of nephrotoxic drugs Presence of renal insufficiency or plasma creatinine higher than 1.3 mg/dL History of gastrointestinal disease or bleeding, peptic ulcer, perioperative bleeding Hepatic insufficiency Ejection fraction less than 40% Postoperative need for intraaortic ballon pump perioperative hemodynamic compromise Unwanter intraoperative events including arrhythmia or cardiac arrest refusal to stay in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: every one and four hours in the first and second days, respectively after intervention. Method of measurement: Observation (CPOT0 and questioning (NRS) scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional analgesic requirement. Timepoint: every one hour on the first day and every 4 hours on the second day. Method of measurement: Recording the amount of administered fentanyl in micro-gram.;Frequency of acute kidney injury. Timepoint: Every day after intervention until discharge from the hospital. Method of measurement: AKIN criteria.;Frequency of gastrointestinal bleeding and discomfort. Timepoint: every day after intervention until discharge from the hospital. Method of measurement: Observation and questioning. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahram Amini
Maragheh University of Medical Sciences
Outcome results
None listed