Comparison of Changes in Heart Rate following Reversal of Muscle Relaxation by Two Combination :Atropine Plus Neosigmine or Glycopyrrolate Plus Neostigmin

Comparison of Changes in Heart Rate and Development Cardiac Arrhythmia following Reversal of Muscle Relaxation by Two Combination :Atropine Plus Neosigmine or Glycopyrrolate Plus Neostigmin

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015021019470N16

Enrollment

100

Registered

2015-04-21

Start date

2010-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract. Senile Cataract

Interventions

Intervention 1: at the end of the operation reversal of the muscle relaxant effects in group I was conducted with combination of atropine-neostigmine. Intervention 2: at the end of the operation rev

Treatment - Drugs

at the end of the operation reversal of the muscle relaxant effects in group I was conducted with combination of atropine-neostigmine

at the end of the operation reversal of the muscle relaxant effects in group ?? was conducted with combination of glycopyrrolate-neostigmine .

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patient between 50-70 year old, ASA physical status I, undergoing cataract surgery under general anesthesia with endotracheal tube or laryngeal mask. Exclusion criteria: Patients with electrolyte abnormalities, cardiovascular problems and using the drugs that affect heart rate and also patients with difficult intubation were excluded from the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG.;Arrhythmia. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG.;Blood Pressure. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: Measuring the blood pressure.	—

Measure

Time frame

Heart Rate. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG.;Arrhythmia. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG.;Blood Pressure. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: Measuring the blood pressure.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mehdi Zadmehr

Shiraz University of Medical Sciences

masihifarzaneh@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026