chronic periodontitis. Chronic periodontitis
Conditions
Interventions
Intervention 1: Intervention group: After the primary sampling, scaling and oral hygiene education, by split-mouth protocol for each patient in one quadrant (which will be selected by randomization by
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Having mild to moderate chronic periodontitis (bone crest distance from CEJ>2, Clinical Attachment Loss=3) Having at least 20 teeth Not having a bridge, crown, or orthodontic braces in the gel application area Having at least 2 pockets with 4-7mm of probing depth and CAL of equal to or greater than 3mm
Exclusion criteria
Exclusion criteria: Having systemic diseases Nonconformity of the prescribed diet Pregnancy and lactation Showing coronavirus disease symptoms or similar symptoms Receiving periodontal treatment and/or usage of antibiotics during 1 month before treatment Presence of aggressive periodontitis and systemic conditions affecting the periodontal condition Malnutrition and impaired immune status Smoking Using statins or allergy to them Using drugs that affect oral tissues Use of antibiotics Use of cholesterol-lowering drugs such as statins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean IL-17 level. Timepoint: At baseline (before the intervention) and at 3 months after gel application. Method of measurement: ELISA Il-17 Human Kit.;Mean TGF-ß level. Timepoint: At baseline (before the intervention) and at 3 months after gel application. Method of measurement: ELISA TGF-ß Human Kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSima Kiani
Esfahan University of Medical Sciences
Outcome results
None listed