Evaluating the efficacy of Bromelain on donor wound healing after free gingival surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201502089002N5

Enrollment

Registered

2015-03-15

Start date

2014-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival recession. Gingival recession (generalized)(localized)(postinfective)(post-operative)

Interventions

Intervention 1: Intervention group : Bromelain (capsule 500mg, oral , once a day for 10 days ). Intervention 2: Control group : placebo (capsul , oral , once a day for 10 days ).

Treatment - Drugs

Intervention group : Bromelain (capsule 500mg, oral , once a day for 10 days )

Control group : placebo (capsul , oral , once a day for 10 days )

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: In this study , individuals who refer to treatment of gingival recession in the anterior site of the mandible that candidate to free gingival graft surgery and have thease criteria will choose: -One of the mandibullar central incisor has Miller class 1,2 or 3 gingival recession. -Systemically healthy -Don't use anticoagulatory drugs like Warfarin. - Didn't use antibiotic and corticosteroid at least during the past tow months. -Aren't smoker or don't smoke more than 10 cigarette. -The mesdames aren't pregnant or lactiferrous .

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Complete epithelialization of donor site. Timepoint: 7 days after surgery ang 10 days after surgery. Method of measurement: To evaluate of epithelialization, 3% hydrogen peroxide apply to the wound by a brush. If the epithelialization is completed, then hydrogen peroxide dose not diffuse into the connective tissue, and oxygen is not librated, ther for any bubble dose not observe.Otherwise , the epithelialization isn't completed.;Pain. Timepoint: 7 days after surgery. Method of measurement: VAS.;The number of analgesic tablets that take by the patients. Timepoint: 7 days after surgery. Method of measurement: the number that reported by the patients.	—

Measure

Time frame

Complete epithelialization of donor site. Timepoint: 7 days after surgery ang 10 days after surgery. Method of measurement: To evaluate of epithelialization, 3% hydrogen peroxide apply to the wound by a brush. If the epithelialization is completed, then hydrogen peroxide dose not diffuse into the connective tissue, and oxygen is not librated, ther for any bubble dose not observe.Otherwise , the epithelialization isn't completed.;Pain. Timepoint: 7 days after surgery. Method of measurement: VAS.;The number of analgesic tablets that take by the patients. Timepoint: 7 days after surgery. Method of measurement: the number that reported by the patients.

—

Secondary

Measure	Time frame
Bleeding. Timepoint: 7 days after surgery. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFahime khoshkhooie

School of dentistry

fahime_khoshkhooie68@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026