The effect of Tribulus terrestris in runners

The effect of Tribulus terrestris supplementation on the nutritional, oxidative, inflammatory, and anti-inflammatory status and sport performance in runners

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20150205020965N8

Enrollment

Registered

2021-02-13

Start date

2021-02-20

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

runners. Activity, running

Interventions

Intervention 1: Intervention group: The intervention group will consume two capsules of Tribulus terrestris (500 mg) each day, which is accompanied by high-intensity interval training. One of the caps

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: The age range of 18 to 35 years Do running workouts for at least 3 days a week (240 minutes per week) during the last 2 years Complete health (confirmed by PAR-Q questionnaire under the supervision of a doctor) The body mass index of 18.5-25 Not receiving Tribulus terrestris supplement in the last three months Not doing high-intensity interval training during the last two weeks Willingness to cooperate in the study

Exclusion criteria

Exclusion criteria: Musculoskeletal injuries Smoking Alcohol consumption Hormone therapy Long-term use of drugs and dietary supplements Intake of antihypertensives, diuretics and antidiabetics Pregnancy Lactation Diabetes Anemia (Hb <13g / dl) Cardiovascular disease Infectious diseases Gastrointestinal problems Malignancies Cognitive disorders

Design outcomes

Primary

Measure	Time frame
Malondialdehyde. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Total antioxidant capacity. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Superoxide dismutase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Hs-CRP. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;IL-6. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;IL-10. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Creatine kinase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Lactate dehydrogenase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Sport performance. Timepoint: At baseline and two weeks after baseline. Method of measurement: questionnaire.;Ferritin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Serum iron. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Insulin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Glucose. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Insulin-like Growth Factor-1. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Adiponectin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;PGC-1alpha expression. Timepoint: At baseline and two weeks after baseline. Method of measurement: pcr.;Tumor necrosis factor alpha. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;a1-acid glycoprotein. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Myoglobin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Irisin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Cortisol. Timepoint: At baseline and two weeks	—

Measure

Time frame

Malondialdehyde. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Total antioxidant capacity. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Superoxide dismutase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Hs-CRP. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;IL-6. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;IL-10. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Creatine kinase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Lactate dehydrogenase. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Sport performance. Timepoint: At baseline and two weeks after baseline. Method of measurement: questionnaire.;Ferritin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Serum iron. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Insulin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Glucose. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Insulin-like Growth Factor-1. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Adiponectin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;PGC-1alpha expression. Timepoint: At baseline and two weeks after baseline. Method of measurement: pcr.;Tumor necrosis factor alpha. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;a1-acid glycoprotein. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Myoglobin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Irisin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Cortisol. Timepoint: At baseline and two weeks

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Secondary

Measure	Time frame
Nutritional status (energy and macronutrients intake). Timepoint: At baseline and two weeks after baseline. Method of measurement: 3-days food intake record.;Body composition. Timepoint: At baseline and two weeks after baseline. Method of measurement: (BIA, BC-418 MA).;Transferrin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;CBC. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Serum iron. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Sleep. Timepoint: At baseline and two weeks after baseline. Method of measurement: Questionnaire.;Recovery and stress. Timepoint: At baseline and two weeks after baseline. Method of measurement: Questionnaire.	—

Measure

Time frame

Nutritional status (energy and macronutrients intake). Timepoint: At baseline and two weeks after baseline. Method of measurement: 3-days food intake record.;Body composition. Timepoint: At baseline and two weeks after baseline. Method of measurement: (BIA, BC-418 MA).;Transferrin. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;CBC. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Serum iron. Timepoint: At baseline and two weeks after baseline. Method of measurement: Kit.;Sleep. Timepoint: At baseline and two weeks after baseline. Method of measurement: Questionnaire.;Recovery and stress. Timepoint: At baseline and two weeks after baseline. Method of measurement: Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvin Dehghan

Tabriz University of Medical Sciences

dehghan.nut@gmail.com+98 41 3334 0634

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 14, 2026