Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: In this study, Camelina oil will be replaced with 15% of the daily total fat intake for three months. Then, 15 days before the beginning of study, FFQ questionnaire will be completed f
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range 20 to 65 years BMI=25 No weight changes over the past 3 months Restricted Consumption of edible nuts and fish Tendency to use camelina oil Having grade 1 and 2 of non-alcoholic fatty liver disease
Exclusion criteria
Exclusion criteria: Having other liver disease apart from NAFLD (alcoholic fatty liver, viral hepatitis, cirrhosis and biliary obstruction, liver cancer)) Liver transplantation Pregnancy and Lactation Kidney, Cardiovascular Disease Alcohol and tobacco consumption high physical activity having acute illness Use of drugs such as glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDS), hepatotoxic drugs, antibiotics Use antioxidant supplements and W3 history of using weight loss diet or a special diet over the past 6 months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index (BMI). Timepoint: At baseline and three months after baseline. Method of measurement: Scale-Meter.;Amount of received energy. Timepoint: At baseline and three months after baseline. Method of measurement: questionnaire.;Daily macronutrient intake (carbohydrate, protein, fat). Timepoint: At baseline and three months after baseline. Method of measurement: questionnaire.;Waist circumference (WHR). Timepoint: At baseline and three months after baseline. Method of measurement: Calculate by splitting waist to hip.;Blood pressure. Timepoint: At baseline and three months after baseline. Method of measurement: Mercuric barometr.;Assessment of the body composition. Timepoint: At baseline and three months after baseline. Method of measurement: BIA devices. | — |
Primary
| Measure | Time frame |
|---|---|
| ALT. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;AST. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;ALP. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;Degree of hepatic steatosis. Timepoint: At baseline and three months after baseline. Method of measurement: Ultrasound.;Fasting glucose. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;Insulin Sensitivity Index (QUICK). Timepoint: At baseline and three months after baseline. Method of measurement: Computing.;Insulin Resistance Index (HOMA-IR). Timepoint: At baseline and three months after baseline. Method of measurement: Computing.;Fasting insulin. Timepoint: At baseline and three months after baseline. Method of measurement: Chemoluminescense.;Total cholestrol. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;HDL-cholesterol. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;LDL-cholesterol. Timepoint: At baseline and three months after baseline. Method of measurement: calculation of LDL using friedewald equation.;Triglyceride. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;Highly sensitive C-reactive protein(hs-CRP ). Timepoint: At baseline and three months after baseline. Method of measurement: ELISA Dedicated Kit.;Tumor Necrosis Factor(TNF). Timepoint: At baseline and three months after baseline. Method of measurement: ELISA Dedicated Kit.;Interleukin 10(IL10 ). Timepoint: At baseline and three months after baseline. Method of measurement: ELISA Dedicated Kit.;Total antioxidant capacity. Timepoint: At baseline and three months after baseline. Method of measurement: kit.;Malondialdehyde. Timepoint: At baseline | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParvin Dehghan
Tabriz University of Medical Sciences
Outcome results
None listed