Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: In this study, Camelina oil will be replaced with 15% of the daily total fat intake and patients will receive two of 5-mg dextrin-resistant doses every day for three months. Then, 15 d
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range 20 to 65 years BMI=25 Edible nuts and fish consumption restriction Tendency to use camelina oil and prebiotic Having grade 1 and 2 fatty liver disease
Exclusion criteria
Exclusion criteria: Having other liver disease apart from NAFLD (alcoholic fatty liver, viral hepatitis, cirrhosis and biliary obstruction, liver cancer) Liver transplantation Pregnancy, Lactation Having kidney, Cardiovascular Disease Alcohol Consumption and smoking High physical activity Having acute illness Use of drugs such as glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDS), hepatotoxic drugs, antibiotics Taking antioxidant supplements and W3 history of losing weight over the past 6 months or a special diet Unwillingness to use prebiotics Gastrointestinal symptoms incidence during the study Weight changes over the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;AST. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;ALP. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;Degree of hepatic steatosis. Timepoint: At baseline and three months after baseline. Method of measurement: sonography.;Fasting glucose. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;Insulin Sensitivity Index (QUICK). Timepoint: At baseline and three months after baseline. Method of measurement: calculation.;Insulin Resistance Index (HOMA-IR). Timepoint: At baseline and three months after baseline. Method of measurement: calculation.;Fasting insulin. Timepoint: At baseline and three months after baseline. Method of measurement: kit.;Total -cholesterol. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;HDL-cholesterol. Timepoint: At baseline and three months after baseline. Method of measurement: Hitachi 911 auto-analyzer.;LDL-cholesterol. Timepoint: At baseline and three months after baseline. Method of measurement: calculation.;Triglyceride. Timepoint: At baseline and three months after baseline. Method of measurement: Autoanalyzer - Hitachi 911.;Highly sensitive C-reactive protein(hs-CRP ). Timepoint: At baseline and three months after baseline. Method of measurement: Kit.;Tumor Necrosis Factor (TNF). Timepoint: At baseline and three months after baseline. Method of measurement: ELISA Kit.;Interleukin 10(IL10 ). Timepoint: At baseline and three months after baseline. Method of measurement: ELISA Kit.;Total antioxidant capacity. Timepoint: At baseline and three months after baseline. Method of measurement: kit.;Malondialdehyde. Timepoint: At baseline and three months after baseline. Method of measurement: kit.;8-iso-prostagl | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index (BMI). Timepoint: At baseline and three months after baseline. Method of measurement: Calculation.;Amount of received energy. Timepoint: At baseline and three months after baseline. Method of measurement: Questionnaire.;Daily carbohydrate intake. Timepoint: At baseline and three months after baseline. Method of measurement: Questionnaire.;Daily protein intake. Timepoint: At baseline and three months after baseline. Method of measurement: Questionnaire.;Daily fat intake. Timepoint: At baseline and three months after baseline. Method of measurement: Questionnaire.;Daily fiber intake. Timepoint: At baseline and three months after baseline. Method of measurement: Questionnaire.;Weight. Timepoint: At baseline and three months after baseline. Method of measurement: Scale.;Waist circumference (WC). Timepoint: At baseline and three months after baseline. Method of measurement: Tape.;Hip circumference (HC). Timepoint: At baseline and three months after baseline. Method of measurement: Tape.;Waist circumference (WHR) ________________________________________. Timepoint: At baseline and three months after baseline. Method of measurement: Calculation.;Blood pressure. Timepoint: At baseline and three months after baseline. Method of measurement: Mercury barometer.;Body composition. Timepoint: At baseline and three months after baseline. Method of measurement: BIA devices. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParvin Dehghan
Tabriz University of Medical Sciences
Outcome results
None listed