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The effect of royal jelly, spirulina, and their combination on muscle damage, inflammation, oxidative stress, body composition, and athletic performance

The effect of royal jelly, spirulina and their combination on exercise induced muscle damage, inflammatory markers, oxidative stress, body composition and athletic performance in recreational resistance training athletes

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150205020965N14
Enrollment
44
Registered
2026-03-06
Start date
2026-04-04
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recreational resistance training athletes.

Interventions

Intervention 1: Intervention group 1: For 8 weeks, participants will receive one 4-g sachet of the combined supplement (containing 2 g royal jelly and 2 g spirulina) daily, half an hour before breakfa

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor
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Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Participants who are within the age range of 18 to 35 years (adults) Participants whose gender is male Participants who have performed traditional dynamic resistance training (bodybuilding and fitness) using combined concentric and eccentric movements at intensities above 65% of one-repetition maximum, at least three times per week during the past year Participants who routinely perform bench press and squat exercises in their training programs Participants who are in good overall health, confirmed through the PAR-Q questionnaire and verified by a physician Participants who have maintained stable body mass over the past five months, with weight changes of less than 3 kilograms Participants who have not consumed any sports supplements within the past month Participants who are willing to cooperate throughout the study and have completed the informed consent form

Exclusion criteria

Exclusion criteria: Participants who are allergic to bee products or seafood Participants who consume alcohol, cigarettes, hookah, or drugs Participants who use anti-inflammatory medications Participants who have followed special or unusual diets in the past six months Participants who are undergoing hormone therapy Participants who have chronic diseases requiring medication Participants whose weight is less than 40 kilograms Participants who have donated blood within the past month Participants whose hemoglobin level is below 13 g/dL Participants with thyroid problems or other chronic diseases Participants with conditions that affect their exercise capacity Participants who have undergone surgery in the past three months

Design outcomes

Primary

MeasureTime frame
Creatine kinase. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.;Lactate dehydrogenase. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.

Secondary

MeasureTime frame
Interleukin-6. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.;High-sensitivity C-reactive protein. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.;Malondialdehyde. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.;Total anti-oxidant capacity. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Kit.;Weight. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Digital scale.;Height. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Meter.;Body mass index. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Body weight divided by height squared.;Body composition. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Bioelectrical impedance analysis.;1 Repetition maximum. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Standardized test.;Repetitions to failure. Timepoint: At baseline and and 8 weeks after the start of the study. Method of measurement: Standardized test.;Food intake. Timepoint: Once in the week before the start of the interventions at baseline and once in the final week of the interventions. Method of measurement: 3-days food record questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvin Dehghan

Tabriz University of Medical Sciences

dehghan.nut@gmail.com+98 41 3335 7580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026