Skip to content

The effect of citrulline malate supplementation on nutritional, oxidative, inflammatory and anti- inflammatory and muscle damage status in adolescent gymnasts with HIIT training

The effect of citrulline malate supplementation on nutritional, oxidative, inflammatory and anti- inflammatory and muscle damage status in adolescent gymnasts with HIIT training

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20150205020965N13
Enrollment
44
Registered
2025-07-08
Start date
2025-06-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adolescent gymnasts.

Interventions

Intervention 1: Intervention group: Intervention group: The intervention group will consume a 4-gram sachet of citrulline malate supplement daily, one hour before training, for a duration of 2 months

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
10 Years to 14 Years

Inclusion criteria

Inclusion criteria: Age range: 10 to 14 years. BMI-for-age (BMI/A) between the 25th and 75th percentiles. Minimum of 2 years of sports experience and Prior participation in provincial or national competitions. No engagement in high-intensity interval training within the past 3 months Participation in standard training routines for competition preparation. Willingness to cooperate throughout the study. Informed consent signed by parents.

Exclusion criteria

Exclusion criteria: history of illness or injury. Presence of eating disorders. use of sports supplements in the past 6 months. use of antioxidant or anti-inflammatory supplements, pain relief medications, or anti-inflammatory drugs.

Design outcomes

Primary

MeasureTime frame
Total anti-oxidant capacity (TAC). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Interleukin 6 (IL-6). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Creatine kinase (CK). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Nitric oxide (NO). Timepoint: At baseline and and two months after the start of the study. Method of measurement: Kit.;Malondialdehyde (MDA). Timepoint: At baseline and two months after start of the study. Method of measurement: kit.;High Sensitive C-reactive protein ( hs-CRP). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Interleukin 10 ( IL-10). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Superoxide dismutase (SOD). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Catalase (CAT). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Glutathione peroxidase (GPx). Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.;Total oxidant status. Timepoint: At baseline and and two months after the start of the study. Method of measurement: kit.

Secondary

MeasureTime frame
Weight , height , BMI. Timepoint: At baseline and two months after baseline. Method of measurement: Scale-Meter.;Body composition. Timepoint: At baseline and two months after baseline. Method of measurement: body analyzer.;Food intake. Timepoint: At baseline and two months after baseline. Method of measurement: 3-days food record questionnaire.;Sleep quality. Timepoint: At baseline and two months after start of the study. Method of measurement: Pittsburgh Sleep Quality Index (PSQI).;Anaerobic leg power. Timepoint: En At baseline and two months after start of the study. Method of measurement: Bosco test (Ergo Jump).;Upper body Muscular endurance. Timepoint: At baseline and two months after start of the study. Method of measurement: Push-up test.;Complete Blood Count. Timepoint: At baseline and two months after start of the study. Method of measurement: Hematology Analyzer.;Muscle soreness. Timepoint: At baseline and two months after start of the study. Method of measurement: Visual Analog Scale questionnaire (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvin Dehghan

Tabriz University of Medical Sciences

dehghan.nut@gmail.com+98 41 3335 7580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026