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Comparison of short agonist vs long agonist stimulation protocol and different pretreatment s in women undergoing in vitro fertlization.

Estradiol valerate pretreatment in short protocol GnRH-agonist cycles versus combined pretreatment with oral contraceptive pills in long protocol GnRH-agonist cycles: a randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015020418202N4
Enrollment
298
Registered
2015-02-27
Start date
2013-07-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility, unspecified

Interventions

Intervention 1: Estradiol valerate pretreatment (2mg oral estradiol twice daily from the 20th day of cycle until 1-4th day of new cycle. in short protocol GnRH-agonist cycles (150-225 IU/day hMG conti
Treatment - Drugs
Estradiol valerate pretreatment (2mg oral estradiol twice daily from the 20th day of cycle until 1-4th day of new cycle. in short protocol GnRH-agonist cycles (150-225 IU/day hMG continued with a dail
Combined pretreatment with oral contraceptive pills (Ovulostan from 2nd to 4th day of cycle) in long protocol GnRH-agonist cycles ( 0.1 mg Triptorelin beginning on the 14th day of the cycle, every 2 d

Sponsors

Invicta Fertility and Reproduction Centre sp.z o.o.
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion: women younger than 40 years old; an AMH level greater than 0.6 ng/mL; a body mass index between 18 and 29 kg/m2; first or second treatment cycle of IVF with intracytoplasmic sperm injection (ICSI). Exclusion: endometriosis; preimplantation diagnosis cycles

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pregnancy rate. Timepoint: on 6 weeks and 1-3 days. Method of measurement: clinical poregnancy (as ultrasound fetal heartbeat detection).

Secondary

MeasureTime frame
Implantation rate. Timepoint: 7 days after tansfer. Method of measurement: blood serum beta-HCG concentration.

Countries

Poland

Contacts

Public ContactJudyta Zabielska

Invicta Fertility and Reproduction Centre sp.z o.o.

judyta.zabielska@invicta.pl0048585858800

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026