Evaluation of the efficacy of atorvastatin mouthwash 1% in prevention of radiotherapy induced oral mucositis.

Evaluation of the efficacy of atorvastatin mouthwash1% in prevention of radiotherapy induced oral mucositis on cancer patients in tehran city.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201502033014N9

Enrollment

Registered

2015-06-04

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucositis. ??????? ????? ( ??? ????? )

Interventions

Intervention 1: Intervention 1 : ??Atorvastatin 1% mouthwas 5ml , 4 times a day for 4 week . Intervention 2: Intervention 2 : placebo mouthwash, 5ml, 4 times a day for 4 week .

Prevention

Intervention 1 : ??Atorvastatin 1% mouthwas 5ml , 4 times a day for 4 week .

Intervention 2 : placebo mouthwash, 5ml, 4 times a day for 4 week .

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Cancer patients between 18-70 years receiving 5-fluorouracil containing chemotherapy regimens. Exclusion criteria: Sucralfate intolerance or inappropriate use of the mouth wash

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Oral mucositis. Timepoint: Every 3 days. Method of measurement: Use of the WHO table and ruler.	—

Secondary

Measure	Time frame
Pain. Timepoint: After 1 month of intervention. Method of measurement: Quastionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMelika Namdari

Vice chancellor for research, Mazandaran University of Medical Sciences

Sh204ala@yahoo.com ; Sala@mazums.ac.ir ; Namdarimelika@gmail.com00981513543083 00989111251309

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026