The effect of preoperative vitamin D administration on postoperative serum levels of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-alpha in patients undergoing elective CABG

The effect of preoperative 1, 25 (OH)2 vitamin D administration on postoperative serum levels of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-alpha in patients undergoing elective CABG

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201502022804N7

Enrollment

Registered

2015-05-17

Start date

2015-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery bypass graft. Atherosclerotic heart disease

Interventions

Intervention 1: In the intervention group, the patients receive 3 vitamin D pearls each day (each pearl is 50000 units

so 150000 units of vitamin D in each day)

these pearls start 1 week before surgery The pearls are made by Dana Pharmaceuticals, Tabriz, Iran. Intervention 2: The control group receives placebo, 3 times a day before one week starting before op

Treatment - Drugs

Placebo

In the intervention group, the patients receive 3 vitamin D pearls each day (each pearl is 50000 units

these pearls start 1 week before surgery The pearls are made by Dana Pharmaceuticals, Tabriz, Iran

The control group receives placebo, 3 times a day before one week starting before operation

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 40-75; elective Coronary Artery Bypass Graft with CardioPulmonary Bypass; constant surgeon Exclusion criteria: informed written consent; diabetes mellitus; chronic kidney disease causing serum Cr>2mg/dL; hepatic failure causing liver function test failure; high levels of vitamin D; off pump Coronary Artery Bypass Graft; any unwanted complication in the operation period; re-starting CPB after weaning from bypass; Pulmonary artery pressure >30 before operation; Ejection Fraction<30%; re-operation in the postoperative period

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum cytokines after CABG. Timepoint: serum cytokines are measure preoperatively as baseline and the after operation. Method of measurement: serum levels detected by ELISA.	—

Secondary

Measure	Time frame
Duration of surgery. Timepoint: duration of anesthesia. Method of measurement: cardiopulmonary bypass time.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Dabbagh

Anesthesiology Research Center

alidabbagh@yahoo.com; alidabbagh@sbmu.ac.ir0000982122432572; 00982122074090

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026